Bonhoeffer et al (Arch Dis Childh 91:929-935, 2006) suggest that vaccinations scheduled at 2, 3 and 4 months after birth for pre-term infants would be safe and effective in reducing the impact of serious infections in these vulnerable babies. An early booster dose would also be required. In many centres, vaccinations for pre-term babies are delayed to 2,4,6 months or even 3-5-11 months based on the fact that antibody responses to the vaccines are relatively low in these immature babies during their early weeks of post-natal life. In their extensive review, the authors point out that while such levels are lower than would be found in term babies, they would be protective, using the 2,3 and 4 month schedule. What do you think? It seems that the issue is of sufficient importance to warrant a full scale evaluation.